2007–2010: Sacredly Agnezious Mnica and Indonesian Idol

In early 2007, Agnes was appointed by the Drug Enforcement Administration (DEA) and the International Drug Enforcement Conference (IDEC) Far East Region as an Asian anti-drug ambassador. On 15 May 2007, she was an opening act for American R&B group, Boyz II Men, at a concert in Istora Senayan, Jakarta, and on 23 June of that year, she held her first concert at Stadium Negara in Kuala Lumpur, Malaysia She also guest starred in the finale of Asian Idol on 16 December 2007, and performed the song "Get Up".

In 2008, Agnes began working on her third studio album. She released the first single, "Matahariku", earlier than she had planned. It became her best-selling single, with sales of three million ringback tone downloads within nine months. The song received the "Most Favorite Female" award at the 2008 MTV Indonesia Awards and the "Best Female Solo Pop Artist" award at the 2009 Anugerah Musik Indonesia.^[33][34] In September 2008, she released the second single, "Godai Aku Lagi", which she wrote herself. She also released a mini album containing the two singles. That same year, she starred in two RCTI soap operas, Jelita and Kawin Masal.

On 4 October 2008, Agnes was invited as the Indonesian representative at the Asia Song Festival in  South Korea. She performed with 24 artists from 12 Asian countries at the Seoul World Cup Stadium. The event was broadcast to 30 countries. She performed two songs from her upcoming album, "Godai Aku Lagi" and "Shake It Off". During the performance, she incorporated elements of Indonesian traditional dance from Bali. Her performance received positive responses from the Korean media and won the committee's "Best Asian Artist Award". The following year, she was invited again alongside 14 Asian artists and performed three songs: "Shake It Off", "Temperature", and Michael Jackson's song, "Heal the World As was the case with her previous performance, Agnes received good reviews and earned the "Best Asian Artist Award".

 Agnes launched her third studio album on 1 April 2009, Sacredly Agnezious. This time, she was involved more in the album production. She worked with the renowned musicians: Erwin Gutawa, Dewiq, Pay, and DJ Sumantri. She also acted as producer and songwriter. In addition to "Matahariku" and "Godai Aku Lagi", the album yielded two more singles: "Teruskanlah" and "Janji–Janji". At the 2010 Anugerah Musik Indonesia, she won three awards: "Best Pop Album", "Best Female Pop Solo Artist", and "Best of the Best Album".On 23 May 2009, she appeared as a guest star at the "Festival of Life" in Garuda Wisnu Kencana, Bali. The celebration commemorated the 50-year anniversary of the establishment of diplomatic relations between Indonesia and Japan.

In 2010, Agnes joined the judging panel of the season 6 of Indonesian Idol. That year, she was also appointed as an ambassador of the MTV EXIT (End Exploitation and Trafficking) organization, which combats human trafficking. In addition to her role as a spokesperson of MTV Exit Indonesia, she also performed at concerts in Surabaya and Jakarta. In late 2010, Agnes was chosen as an international red carpet host for the annual American Music Awards On 21 November 2010 at the Nokia Theatre in Los Angeles. Several months after that appearance, she announced that she had signed to Sony/ATV Music Publishing and was working on her international debut in London and Los Angeles.